DCAF8 Gene Summary [Human]

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

Details

Type
Protein Coding
Official Symbol
DCAF8
Official Name
DDB1 and CUL4 associated factor 8 [Source:HGNC Symbol;Acc:HGNC:24891]
Ensembl ID
ENSG00000132716
Bio databases IDs NCBI: 50717 Ensembl: ENSG00000132716
Aliases DDB1 and CUL4 associated factor 8
Synonyms AA433120, D1Dau35e, D1Ucla4, DDB1 and CUL4 associated factor 8, GAN2, H326, RGD1308513, WDR42A
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCAF8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • WD40 repeats
  • WD domain, G-beta repeat
  • WD40
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • lung squamous cell carcinoma
  • squamous cell lung cancer
  • preeclampsia
  • autosomal dominant giant axonal neuropathy 2
regulated by
regulates
  • MYH6
  • mir-217 (includes others)
role in cell
  • degradation in
  • atrophy

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • Mitochondria
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human DCAF8 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein ubiquitination

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • mitochondrion
  • cytosol
  • CUL4 RING ubiquitin ligase complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.