TRIM28 Gene Summary [Human]
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM28 |
| Official Name | tripartite motif containing 28 [Source:HGNC Symbol;Acc:HGNC:16384] |
| Ensembl ID | ENSG00000130726 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 28, protein phosphatase 1, regulatory subunit 157, Transcription intermediary factor 1-beta, RING finger protein 96, KRAB-associated protein 1 |
| Synonyms | Hs.158209, KAP-1, KRAB-ASSOCIATED protein 1, KRIP-1, LOC100502802, MommeD9, PPP1R157, RNF96, TF1B, TIF1B, TIF1beta, Tif1 β, Transcription intermediary factor 1 beta, Transcription intermediary factor 1 β, tripartite motif-containing 28, XSG22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- Nuf2, DHR10-like domain
- PHD zinc finger
- transcription regulator
- protein kinase
- transcription co-activator
- B-Box C-terminal domain
- transcription co-repressor
- chromatin binding
- coiled-coil domain
- Bromodomain
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- B-box zinc finger
- zinc-RING finger domain
- SUMO ligase
- ubiquitin protein ligase binding
- SUMO transferase activity
- ubiquitin protein ligase activity
- protein domain specific binding
- HP1 binding domain
- protein binding
- DNA binding
- transcription repression domain
- B-box-type zinc finger superfamily
- ubiquitin-protein transferase activity
- PHD finger superfamily
Pathways
Biological processes and signaling networks where the TRIM28 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- renal cancer
- opioid dependence
- liver cancer
- oligoastrocytoma
- glioma formation
- castration refractory prostate cancer
- organismal death
- astrocytoma
role in cell
- proliferation
- phosphorylation in
- apoptosis
- expression in
- number
- binding in
- accumulation in
- growth
- activation in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- heterochromatin
- Cytoplasm
- nucleoplasm
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- DNA repair
- positive regulation of protein import into nucleus
- negative regulation of retroviral genome replication
- protein sumoylation
- embryonic placenta morphogenesis
- chromatin organization
- convergent extension involved in axis elongation
- embryo implantation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- innate immune response
- epithelial to mesenchymal transition
- positive regulation of methylation-dependent chromatin silencing
- genetic imprinting
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- euchromatin
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein kinase activity
- chromatin binding
- DNA binding
- ubiquitin-protein ligase activity
- RNA binding
- ubiquitin protein ligase binding
- protein binding
- transcription coactivator activity
- transcription corepressor activity
- chromo shadow domain binding
- Krueppel-associated box domain binding
- SUMO ligase activity