COPZ2 Gene Summary [Human]
This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]
Details
| Type | Retained Intron |
| Official Symbol | COPZ2 |
| Official Name | COPI coat complex subunit zeta 2 [Source:HGNC Symbol;Acc:HGNC:19356] |
| Ensembl ID | ENSG00000005243 |
| Bio databases IDs | |
| Aliases | COPI coat complex subunit zeta 2, nonclathrin coat protein zeta-COP, zeta2-COP, zeta-2 coat protein |
| Synonyms | 1110012D12Rik, coatomer protein complex, subunit zeta 2, coatomer protein complex, subunit ζ 2, COPI coat complex subunit zeta 2, COPI coat complex subunit ζ 2, zeta2-COP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COPZ2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Clathrin adaptor complex small chain
- APS2
- Longin-like domains
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- transport vesicles
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COPZ2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retrograde vesicle-mediated transport, Golgi to ER
- intra-Golgi vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cis-Golgi network
- cytosol
- Golgi membrane
- transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment membrane
- COPI vesicle coat