COPB2 Gene Summary [Human]
The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM, Jul 2002]
Details
| Type | Retained Intron |
| Official Symbol | COPB2 |
| Official Name | COPI coat complex subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:2232] |
| Ensembl ID | ENSG00000184432 |
| Bio databases IDs | |
| Aliases | COPI coat complex subunit beta 2, coatomer protein complex subunit beta prime |
| Synonyms | AI256832, Beta'-coat, Beta Cop, beta'-COP, COPI coat complex subunit beta 2, COPI coat complex subunit β 2, MCPH19, OPDD, p102, Rack2, β'-coat, β Cop, β'-COP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COPB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- protein kinase C binding
- WD domain, G-beta repeat
- WD40
- protein binding
- Coatomer WD associated region
- transporter
Pathways
Biological processes and signaling networks where the COPB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- hereditary disorder
- childhood or juvenile-onset osteoporosis with developmental delay
- autosomal recessive primary microcephaly type 19
- osteoarthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
- infection by Human parainfluenza virus 3
- infection by vesicular stomatitis virus
- infection by lymphocytic choriomeningitis virus
role in cell
- replication in
- cell viability
- cell death
- formation
- growth
- invasion by
- vesicle transport in
- alternative splicing in
- stabilization in
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear Golgi regions
- Golgi region
- cellular membrane
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- Golgi stacks
- trans Golgi network
- mitochondrial inner membrane
- transport vesicles
- axons
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COPB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- intra-Golgi vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- Golgi membrane
- transport vesicle
- COPI vesicle coat
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity