SPAG9 Gene Summary [Human]
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | SPAG9 |
| Official Name | sperm associated antigen 9 [Source:HGNC Symbol;Acc:HGNC:14524] |
| Ensembl ID | ENSG00000008294 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 9, sperm surface protein, JNK/SAPK-associated protein, JNK interacting protein, sperm specific protein, c-Jun NH2-terminal kinase-associated leucine zipper protein, Max-binding protein, JNK-associated leucine-zipper protein, HLC-4 protein, lung cancer oncogene 4, proliferation-inducing gene 6, cancer/testis antigen 89 |
| Synonyms | 3110018C07RIK, 4733401I23Rik, 4831406C20Rik, CT89, HLC4, HLC-6, JIP-4, JLP, JSAP2, JSAP2a, Mapk8ip4, PHET, PIG6, sperm associated antigen 9, syd1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPAG9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- JNK-interacting protein leucine zipper II
- Ezrin/radixin/moesin, alpha-helical domain
- Uso1 / p115 like vesicle tethering protein, C terminal region
- leucine zipper domain
- JUN kinase binding
- protein binding
- Cell division protein ZapB
- identical protein binding
- kinesin binding
- MAP-kinase scaffold protein
- JNK_SAPK-associated protein-1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- periodontitis
- organismal death
- oligozoospermia
- asthenozoospermia
role in cell
- activation in
- accumulation in
- growth
- localization
- accumulation
- differentiation
- migration
- clustering
- clustering in
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPAG9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- MAPK cascade
- vesicle-mediated transport
- striated muscle cell differentiation
- negative regulation of protein phosphorylation
- negative regulation of neuron differentiation
- positive regulation of neuron differentiation
- positive regulation of MAPK cascade
- retrograde transport, endosome to Golgi
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- acrosomal vesicle
- centriolar satellite
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- kinesin binding
- JUN kinase binding
- MAP-kinase scaffold activity
- receptor signaling complex scaffold activity