ZDHHC7
ZDHHC7 Gene Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; polarized epithelial cell differentiation; and regulation of signal transduction. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZDHHC7 |
| Official Name | zinc finger DHHC-type palmitoyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:18459] |
| Ensembl ID | ENSG00000153786 |
| Bio databases IDs | |
| Aliases | zinc finger DHHC-type palmitoyltransferase 7, Sertoli cell gene with zinc finger domain-β |
| Synonyms | DHHC7,Gramp2,Scc2,SERZ-1,SERZ-B,zinc finger, DHHC domain containing 7,zinc finger DHHC-type palmitoyltransferase 7,ZNF370 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the ZDHHC7 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CAV1
- A1BG
- IL18
- ESR1
- CCL8
- TMEM259
- SNAP25
- NUP43
- APP
- CKM
disease
- breast cancer
- impaired glucose tolerance
- lung adenocarcinoma
- lung adenocarcinoma formation
- hyponatremia
- dextran sodium sulfate-induced colitis
- metabolic alkalosis
- hyperglycemia
regulated by
- beta-estradiol
- tetrachlorodibenzodioxin
- FSH
- bucladesine
regulates
- CAMK2A
- IL1B
- STAT3
- SNAP25
- CAV1
- CREB
- SPAG9
- NCAM1
- JAK1
- BSND
role in cell
- phosphorylation in
- binding
- molecular cleavage in
- plasticity
- long-term potentiation
- differentiation
- palmitoylation in
- binding in
- aggregation in
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Mitochondria
- Golgi membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ZDHHC7 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- glucose import in response to insulin stimulus
- polarized epithelial cell differentiation
- peptidyl-L-cysteine S-palmitoylation
- progesterone receptor signaling pathway
- protein palmitoylation
- negative regulation of catabolic process
- regulation of G-protein coupled receptor protein signaling pathway
- androgen receptor signaling pathway
- protein targeting to membrane
- steroid hormone mediated signaling pathway
- protein localization in plasma membrane
CELLULAR COMPONENT
Where in the cell the gene product is active
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- protein-cysteine S-myristoyltransferase activity
- palmitoyltransferase activity