Spag9 Gene Summary [Mouse]
Enables several functions, including JUN kinase binding activity; MAP-kinase scaffold activity; and kinesin binding activity. Acts upstream of or within positive regulation of MAPK cascade; positive regulation of neuron differentiation; and striated muscle cell differentiation. Located in cytoplasm. Is expressed in central nervous system; dorsal root ganglion; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to human SPAG9 (sperm associated antigen 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Spag9 |
| Official Name | sperm associated antigen 9 [Source:MGI Symbol;Acc:MGI:1918084] |
| Ensembl ID | ENSMUSG00000020859 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 9 |
| Synonyms | 3110018C07RIK, 4733401I23Rik, 4831406C20Rik, CT89, HLC4, HLC-6, JIP-4, JLP, JSAP2, JSAP2a, Mapk8ip4, PHET, PIG6, sperm associated antigen 9, syd1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spag9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- JNK-interacting protein leucine zipper II
- Ezrin/radixin/moesin, alpha-helical domain
- Uso1 / p115 like vesicle tethering protein, C terminal region
- leucine zipper domain
- JUN kinase binding
- protein binding
- Cell division protein ZapB
- identical protein binding
- kinesin binding
- MAP-kinase scaffold protein
- JNK_SAPK-associated protein-1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- periodontitis
- organismal death
- oligozoospermia
- asthenozoospermia
role in cell
- activation in
- accumulation in
- growth
- localization
- accumulation
- differentiation
- migration
- clustering
- clustering in
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spag9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- MAPK cascade
- vesicle-mediated transport
- striated muscle cell differentiation
- negative regulation of protein phosphorylation
- negative regulation of neuron differentiation
- positive regulation of neuron differentiation
- positive regulation of MAPK cascade
- retrograde transport, endosome to Golgi
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- acrosomal vesicle
- centriolar satellite
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- kinesin binding
- JUN kinase binding
- MAP-kinase scaffold activity
- receptor signaling complex scaffold activity