ACOT11 Gene Summary [Human]
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Details
| Type | Processed Transcript |
| Official Symbol | ACOT11 |
| Official Name | acyl-CoA thioesterase 11 [Source:HGNC Symbol;Acc:HGNC:18156] |
| Ensembl ID | ENSG00000162390 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 11, StAR-related lipid transfer (START) domain containing 14 |
| Synonyms | 1110020M10Rik, 2010309H15Rik, acyl-CoA thioesterase 11, BFIT, BFIT1, mKIAA0707, STARD14, THEA, THEM1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACOT11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- Thioesterase superfamily
- hot_dog
- enzyme
- protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- obesity
- Huntington disease
- overall survival
- hepatic steatosis
role in cell
- abnormal morphology
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACOT11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- response to cold
- response to temperature stimulus
- fatty acid metabolic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- long-chain acyl-CoA hydrolase activity
- lipid binding
- acyl-CoA hydrolase activity
- carboxylic ester hydrolase activity