RANBP9 Gene Summary [Human]
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RANBP9 |
| Official Name | RAN binding protein 9 [Source:HGNC Symbol;Acc:HGNC:13727] |
| Ensembl ID | ENSG00000010017 |
| Bio databases IDs | |
| Aliases | RAN binding protein 9, Ran Binding Protein in the Microtubule organizing center |
| Synonyms | BPM90, BPM-L, IBAP-1, RAN binding protein 9, RanBP7, RANBPM, RGD1561940 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RANBP9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTLH/CRA C-terminal to LisH motif domain
- SPRY domain
- CT11-RanBPM
- enzyme binding
- Lissencephaly type1-like homology motif
- C-terminal to LisH motif
- protein binding
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- epithelial cancer
- adenocarcinoma
- squamous-cell carcinoma
- squamous cell cancer
- tinnitus
role in cell
- proliferation
- growth
- apoptosis
- activity
- production in
- molecular cleavage in
- number
- formation
- degradation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- Cytoplasm
- Plasma Membrane
- centrosome
- cytosol
- nucleoplasm
- nuclear bodies
- dendrites
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RANBP9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- macromolecular complex assembly
- negative regulation of ERK1 and ERK2 cascade
- microtubule nucleation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- ubiquitin ligase complex
- cytoplasm
- cytosol
- plasma membrane
- microtubule associated complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- enzyme binding