AGTR1 Gene Summary [Human]
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | AGTR1 |
| Official Name | angiotensin II receptor type 1 [Source:HGNC Symbol;Acc:HGNC:336] |
| Ensembl ID | ENSG00000144891 |
| Bio databases IDs | |
| Aliases | angiotensin II receptor type 1 |
| Synonyms | AG2S, AGTR1A, AGTR1B, Angiotensin II receptor 1a, Angiotensin II receptor type 1, angiotensin II receptor, type 1b, Angtr-1a, Angtr-1b, AT1, AT1B, AT1BR, AT1R, AT1Rb, AT1 receptor, AT2R1, AT2R1B, AT3, ATR1, ATR1b, AT<sub>1</sub>R, HAT1R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGTR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- G-protein-coupled receptor binding
- angiotensin type I receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- GRK binding domain
- caveolin binding domain
- angiotensin type II receptor
- cytoplasmic loop
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein heterodimerization
Pathways
Biological processes and signaling networks where the AGTR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiac Fibroblast Signaling Pathway
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Gαi Signaling
- Gαq Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- p70S6K Signaling
- Phagosome Formation
- Renin-Angiotensin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- major depression
- schizoaffective disorder
- depressive disorder
- bipolar disorder
- hypercholesterolemia
- disorder of coronary artery
- primary hypercholesterolemia
- stroke
- insulin-dependent diabetes mellitus
role in cell
- expression in
- apoptosis
- degradation in
- phosphorylation in
- activation in
- migration
- binding in
- chemotaxis
- growth
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- endosomes
- Endoplasmic Reticulum
- caveolae
- endocytotic vesicle
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGTR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- low-density lipoprotein particle remodeling
- cell chemotaxis
- positive regulation of protein metabolic process
- inflammatory response
- renin-angiotensin regulation of aldosterone production
- kidney development
- regulation of renal sodium excretion
- calcium-mediated signaling
- regulation of vasoconstriction
- positive regulation of reactive oxygen species metabolic process
- regulation of systemic arterial blood pressure by renin-angiotensin
- G-protein coupled receptor signaling pathway
- angiotensin-mediated signaling pathway
- positive regulation of inflammatory response
- phospholipase C-activating G-protein coupled receptor signaling pathway
- Rho protein signal transduction
- regulation of blood vessel size by renin-angiotensin
- regulation of cell proliferation
- elevation of cytosolic calcium ion concentration
- regulation of cell growth
- regulation of inflammatory response
- positive regulation of phospholipase A2 activity
- positive regulation of macrophage derived foam cell differentiation
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- angiotensin type II receptor activity
- protein heterodimerization activity
- bradykinin receptor binding
- angiotensin type I receptor activity