GPRC5A Gene Summary [Human]
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | GPRC5A |
| Official Name | G protein-coupled receptor class C group 5 member A [Source:HGNC Symbol;Acc:HGNC:9836] |
| Ensembl ID | ENSG00000013588 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor class C group 5 member A |
| Synonyms | FLJ22182, GPCR5A, G protein-coupled receptor class C group 5 member A, G protein-coupled receptor, class C, group 5, member A, G protein-coupled receptor, family C, group 5, member A, PEIG-1, RAI3, RAIG1, TIG1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPRC5A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPRC5A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic cancer
- metastasis
- prostate cancer
- tumorigenesis
- HER2 negative hormone receptor negative breast cancer
- cutaneous melanoma
- organismal death
- colorectal cancer
- cutaneous melanoma cancer
role in cell
- expression in
- colony formation
- phosphorylation in
- production in
- proliferation
- adhesion
- migration
- growth
- cell viability
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- cellular membrane
- vesicles
- nucleoli
- perinuclear vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPRC5A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epidermal growth factor-activated receptor activity
- G-protein coupled receptor signaling pathway
- signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- vesicle
- receptor complex
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- protein kinase activator activity
- cadherin binding