ACP3 Gene Summary [Human]
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | ACP3 |
| Official Name | acid phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:125] |
| Ensembl ID | ENSG00000014257 |
| Bio databases IDs | |
| Aliases | acid phosphatase 3, prostatic acid phosphatase |
| Synonyms | 5'-NT, A030005E02Rik, acid phosphatase 3, ACPP, Acpp11, FRAP, Lap, PAcp, PAP, Ppal, Prostatic acid phosphatase, RNACPP11, TMPAP, Transmembrane Prostatic Acid Phosphatase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid phosphatase
- 5'-nucleotidase
- binding protein
- thiamin phosphate phosphatase
- phosphatase
- Histidine phosphatase superfamily (branch 2)
- protein homodimerization
- Histidine phosphatase domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- breast cancer
- epithelial cancer
- epithelial neoplasia
- organismal death
- spontaneous hypertension
- thermal hyperalgesia
- psoriasis
- lung cancer
- allodynia
role in cell
- proliferation
- growth
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- apical compartment
- cellular membrane
- Plasma Membrane
- secretory granule membrane
- apical cytoplasm
- basal cytoplasm
- vesicle membrane
- lysosome membrane
- multivesicular bodies
- secretory granules
- Golgi cisternae
- filopodia
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- adenosine metabolic process
- positive regulation of adenosine receptor signaling pathway
- lipid metabolic process
- thiamine metabolic process
- purine base metabolic process
- dephosphorylation
- regulation of sensory perception of pain
- nucleotide metabolic process
Cellular Component
Where in the cell the gene product is active
- multivesicular body
- plasma membrane
- lysosomal membrane
- lysosome
- nucleus
- extracellular space
- extracellular vesicular exosome
- apical part of cell
- vesicle membrane
- filopodium
- cytosol
- Golgi cisterna
- azurophil granule membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- lysophosphatidic acid phosphatase activity
- choline binding
- protein tyrosine phosphatase activity
- 5'-nucleotidase activity
- thiamine phosphate phosphatase activity
- phosphatase activity
- acid phosphatase activity
- binding, bridging