TUBG2 Gene Summary [Human]
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TUBG2 |
| Official Name | tubulin gamma 2 [Source:HGNC Symbol;Acc:HGNC:12419] |
| Ensembl ID | ENSG00000037042 |
| Bio databases IDs | |
| Aliases | tubulin gamma 2 |
| Synonyms | tubulin gamma 2, tubulin γ 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TUBG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- Tubulin/FtsZ family, GTPase domain
- Tubulin/FtsZ family, C-terminal domain
- structural molecule
Pathways
Biological processes and signaling networks where the TUBG2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- follicular B-cell or T-cell lymphoma
- Waldenström macroglobulinemia
- non-Hodgkin disease
- lymphoplasmacytic lymphoma
- low-grade glioma
- stroke
- cerebral infarction
- acute myeloid leukemia
- cancer
- skin cancer
regulated by
- CDKN1A
- paclitaxel
- larotaxel
- cevipabulin
role in cell
- regrowth
- regrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- microtubules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TUBG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic spindle organization
- microtubule nucleation
- mitotic sister chromatid segregation
- cytoplasmic microtubule organization
- mitotic cell cycle
- meiotic spindle organization
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- nucleus
- spindle microtubule
- microtubule cytoskeleton
- centrosome
- cytoplasm
- spindle
- cytosol
- cytoplasmic microtubule
- gamma-tubulin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- structural molecule activity
- structural constituent of cytoskeleton