PDS5A Gene Summary [Human]
The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | PDS5A |
| Official Name | PDS5 cohesin associated factor A [Source:HGNC Symbol;Acc:HGNC:29088] |
| Ensembl ID | ENSG00000121892 |
| Bio databases IDs | |
| Aliases | PDS5 cohesin associated factor A |
| Synonyms | 9030416H16Rik, B230308N11Rik, E230024D05Rik, KIAA0648, PDS5, PDS5 cohesin associated factor A, PIG54, RGD1307094, SCC-112 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDS5A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Sister chromatid cohesion protein PDS5 protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- chromosome
- nucleoplasm
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDS5A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA repair
- mitotic sister chromatid cohesion
- negative regulation of DNA replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome
- chromosome, centromeric region
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding