RAB27B Gene Summary [Human]
Enables guanyl ribonucleotide binding activity; myosin V binding activity; and protein domain specific binding activity. Involved in multivesicular body sorting pathway and positive regulation of exocytosis. Located in Golgi stack and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB27B |
| Official Name | RAB27B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9767] |
| Ensembl ID | ENSG00000041353 |
| Bio databases IDs | |
| Aliases | RAB27B, member RAS oncogene family |
| Synonyms | 2310021G14Rik, B130064M09RIK, C25KG, LOC100507649, LOC108348810, RAB27B, member RAS oncogene family |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB27B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- protein domain specific binding
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- myosin binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- major depression
- neuroticism
- organismal death
- metabolic syndrome X
- bleeding
- Parkinson disease
- paranoia
- oral squamous cell carcinoma
role in cell
- expression in
- proliferation
- apoptosis
- exocytosis
- growth
- survival
- morphology
- exocytosis by
- invasion by
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- secretory granule membrane
- apical membrane
- plasma membrane projections
- Golgi stacks
- dense granule
- alpha granule membranes
- alpha granules
- zymogen granules
- late endosomes
- dense-core vesicles
- melanosomes
- multivesicular bodies
- secretory granules
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB27B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle endocytosis
- multivesicular body sorting pathway
- exocytosis
- positive regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- secretory granule
- trans-Golgi network transport vesicle
- late endosome
- Golgi apparatus
- Golgi stack
- zymogen granule membrane
- plasma membrane
- exocytic vesicle
- extracellular vesicular exosome
- melanosome
- platelet dense granule membrane
- multivesicular body membrane
- synaptic vesicle membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein domain specific binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- myosin V binding