MS4A2 Gene Summary [Human]
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | MS4A2 |
| Official Name | membrane spanning 4-domains A2 [Source:HGNC Symbol;Acc:HGNC:7316] |
| Ensembl ID | ENSG00000149534 |
| Bio databases IDs | |
| Aliases | membrane spanning 4-domains A2, Fc fragment of IgE, high affinity I, receptor for; beta polypeptide |
| Synonyms | APY, ATOPY, Fce1b, Fc epsilon ri beta, FCER1B, FCERI, FCIGA, FcMR I β Chain, FcRB, Fcrbeta, FcR β, Fc ε ri β, High affinity immunoglobulin ε receptor β subunit, Ige fc receptor β subunit, IGEL, IGER, IGHER, membrane spanning 4-domains A2, membrane-spanning 4-domains, subfamily A, member 2, MS4A1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MS4A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- cytoplasmic domain
- SH2-domain binding
- phosphoprotein binding
- protein binding
- membrane-proximal domain
- IgE receptor
- CD20-like family
- transmembrane receptor
- IgE binding
Pathways
Biological processes and signaling networks where the MS4A2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cystic fibrosis
- childrens interstitial lung disease
- allergic asthma
- chronic rhinosinusitis with nasal polyps
- angioedema
- asthma
- food allergy
- chronic idiopathic urticaria
- IgE-mediated food allergy
- chronic urticaria
role in cell
- apoptosis
- transactivation in
- phosphorylation in
- degranulation
- reorganization
- function
- reorganization in
- translocation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomes
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MS4A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- Fc-epsilon receptor I complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- IgE binding