TNIP3 Gene Summary [Human]
Enables polyubiquitin modification-dependent protein binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB signaling; and toll-like receptor signaling pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TNIP3 |
| Official Name | TNFAIP3 interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:19315] |
| Ensembl ID | ENSG00000050730 |
| Bio databases IDs | |
| Aliases | TNFAIP3 interacting protein 3 |
| Synonyms | 9030611K07Rik, ABIN-3, LIND, TNFAIP3 interacting protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNIP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBAN motif
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
- protein binding
- ABIN homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- multiple sclerosis
- soft tissue sarcoma
- breast carcinoma
- soft tissue sarcoma cancer
- ulcerative colitis
role in cell
- activation in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNIP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- MyD88-independent toll-like receptor signaling pathway
- cellular response to lipopolysaccharide
- toll-like receptor 4 signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- polyubiquitin binding