SPO11 Gene Summary [Human]
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SPO11 |
| Official Name | SPO11 initiator of meiotic double stranded breaks [Source:HGNC Symbol;Acc:HGNC:11250] |
| Ensembl ID | ENSG00000054796 |
| Bio databases IDs | |
| Aliases | SPO11 initiator of meiotic double stranded breaks, cancer/testis antigen 35, spermatogenesis associated 43 |
| Synonyms | CT35, SPATA43, Spo11a, Spo11b, SPO11 initiator of meiotic double strand breaks, SPO11 initiator of meiotic double stranded breaks, TOPOVIA, TOPVIA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPO11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type IIB DNA topoisomerase
- TOPRIM
- enzyme
- protein binding
- SPO11 homolog
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPO11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- meiotic DNA double-strand break processing
- reciprocal meiotic recombination
- spermatid development
- spermatogenesis
- male meiosis I
- synaptonemal complex assembly
- meiotic DNA double-strand break formation
- ovarian follicle development
- meiotic telomere clustering
- oogenesis
- protein localization to chromosome
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- protein binding
- metal ion binding
- DNA topoisomerase (ATP-hydrolyzing) activity