Spo11 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Acts upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; oral epithelium; and skin. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spo11 |
| Official Name | SPO11 initiator of meiotic double stranded breaks [Source:MGI Symbol;Acc:MGI:1349669] |
| Ensembl ID | ENSMUSG00000005883 |
| Bio databases IDs | |
| Aliases | SPO11 initiator of meiotic double stranded breaks |
| Synonyms | CT35, SPATA43, Spo11a, Spo11b, SPO11 initiator of meiotic double strand breaks, SPO11 initiator of meiotic double stranded breaks, TOPOVIA, TOPVIA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spo11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type IIB DNA topoisomerase
- TOPRIM
- enzyme
- protein binding
- SPO11 homolog
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spo11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- meiotic DNA double-strand break processing
- reciprocal meiotic recombination
- spermatid development
- spermatogenesis
- male meiosis I
- synaptonemal complex assembly
- meiotic DNA double-strand break formation
- ovarian follicle development
- meiotic telomere clustering
- oogenesis
- protein localization to chromosome
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- protein binding
- metal ion binding
- DNA topoisomerase (ATP-hydrolyzing) activity