ATP11B Gene Summary [Human]
P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]
Details
| Type | Protein Coding |
| Official Symbol | ATP11B |
| Official Name | ATPase phospholipid transporting 11B (putative) [Source:HGNC Symbol;Acc:HGNC:13553] |
| Ensembl ID | ENSG00000058063 |
| Bio databases IDs | |
| Aliases | ATPase phospholipid transporting 11B (putative) |
| Synonyms | 1110019I14Rik, A830055I09Rik, ATPase, class VI, type 11B, ATPase phospholipid transporting 11B (putative), ATPIF, ATPIR, mKIAA0956 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP11B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- Mg2+-ATPase
- phospholipid-translocating P-type ATPase, flippase
- Phospholipid-translocating ATPase N-terminal
- protein binding
- Cation transport ATPase (P-type)
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Phospholipid-translocating P-type ATPase C-terminal
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- septic shock
- prostatic carcinoma
regulates
- ion
- cisplatin
- aminophospholipid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- secretory granule membrane
- lysosome membrane
- endosomal membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP11B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- phospholipid translocation
- aminophospholipid transport
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- nuclear inner membrane
- membrane
- recycling endosome
- Golgi apparatus
- endoplasmic reticulum
- recycling endosome membrane
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- protein binding
- ion transmembrane transporter activity