RAB11A Gene Summary [Human]
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Details
| Type | Processed Transcript |
| Official Symbol | RAB11A |
| Official Name | RAB11A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9760] |
| Ensembl ID | ENSG00000103769 |
| Bio databases IDs | |
| Aliases | RAB11A, member RAS oncogene family |
| Synonyms | RAB11A, member RAS oncogene family, YL8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB11A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- 50S ribosome-binding GTPase
- GTPase
- protein domain specific binding
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- AAA domain
- GTP binding
- myosin binding
- microtubule binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RAB11A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- adenoma formation
- Huntington disease
- neonatal late-onset sepsis
- abdominal aortic aneurysm
role in cell
- degradation in
- expression in
- cell death
- cell cycle progression
- apoptosis
- cell viability
- mobilization
- formation
- morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- synaptic vesicle membrane
- glutaminergic synapse
- endocytic vesicle membrane
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- exocytic vesicle
- discoidal-fusiform vesicle
- intracellular space
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- centriole
- cytosol
- Golgi membrane
- trans Golgi network
- endosomal membrane
- spindle pole
- zymogen granules
- synapse
- recycling endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- peripheral vesicles
- multivesicular bodies
- kinetochore microtubule
- microsomal membrane
- cleavage furrow
- presynaptic terminals
- exosomes
- phagosomes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB11A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- protein transmembrane transport
- neuron projection development
- Golgi to plasma membrane protein transport
- plasma membrane to endosome transport
- regulation of vesicle-mediated transport
- establishment of protein localization in membrane
- exocytosis
- establishment of protein localization to organelle
- astral microtubule organization
- vesicle-mediated transport
- establishment of vesicle localization
- regulation of cytokinesis
- positive regulation of epithelial cell migration
- mitotic metaphase plate congression
- protein localization in plasma membrane
- regulation of endocytic recycling
- regulation of multivesicular body size
- positive regulation of G2/M transition of mitotic cell cycle
- melanosome transport
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- centriolar satellite
- phagocytic vesicle
- spindle pole
- Golgi apparatus
- Golgi membrane
- multivesicular body
- trans-Golgi network
- centrosome
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- centriole
- intracellular membrane-bounded organelle
- kinetochore microtubule
- cytoplasmic vesicle
- cytosol
- vesicle
- recycling endosome
- macromolecular complex
- transport vesicle
- recycling endosome membrane
- trans-Golgi network membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- syntaxin binding
- GTPase activity
- small monomeric GTPase activity
- dynein light intermediate chain binding
- myosin V binding
- microtubule binding