IFNA21 Gene Summary [Human]
This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | IFNA21 |
| Official Name | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] |
| Ensembl ID | ENSG00000137080 |
| Bio databases IDs | |
| Aliases | interferon alpha 21, leukocyte interferon protein |
| Synonyms | IFN-alphaI, interferon alpha 21, interferon α 21, LeIF F |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNA21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- IFab
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the IFNA21 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- IL-15 Production
- Interferon Signaling
- Neuroinflammation Signaling Pathway
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multisystem inflammatory syndrome in children
- psoriasis
role in cell
- activation in
- expression in
- proliferation
- phosphorylation in
- production in
- transactivation in
- activation
- maturation
- differentiation
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNA21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- natural killer cell activation involved in immune response
- B cell differentiation
- response to exogenous dsRNA
- cytokine-mediated signaling pathway
- humoral immune response
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- defense response to virus
- B cell proliferation
- adaptive immune response
- T cell activation involved in immune response
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interferon-alpha/beta receptor binding
- cytokine activity
- cytokine receptor binding