DGKG Gene Summary [Human]
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | DGKG |
| Official Name | diacylglycerol kinase gamma [Source:HGNC Symbol;Acc:HGNC:2853] |
| Ensembl ID | ENSG00000058866 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase gamma |
| Synonyms | 2900055E17Rik, DAGK3, DGK-GAMMA, DGK-III, DGK-γ, diacylglycerol kinase gamma, diacylglycerol kinase, gamma, diacylglycerol kinase γ, diacylglycerol kinase, γ, E430001K23Rik, mKIAA4131 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DGKG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- diacylglycerol kinase
- EF-hand domain pair
- C1A domain
- EFh
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- Diacylglycerol kinase N-terminus
- lipid kinase, YegS/Rv2252/BmrU family
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- C1B domain
- Diacylglycerol kinase catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- obesity
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- major depression
- metabolic disorder
- spine abnormality
- survival
- acute myeloid leukemia
role in cell
- activation
- formation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- cell periphery
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DGKG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendrite development
- negative regulation of protein kinase C signaling cascade
- glycerolipid metabolic process
- neuron development
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- lipid phosphorylation
- phosphatidic acid biosynthetic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium ion binding
- lipid binding
- diacylglycerol kinase activity