FBXW8 Gene Summary [Human]
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FBXW8 |
| Official Name | F-box and WD repeat domain containing 8 [Source:HGNC Symbol;Acc:HGNC:13597] |
| Ensembl ID | ENSG00000174989 |
| Bio databases IDs | |
| Aliases | F-box and WD repeat domain containing 8 |
| Synonyms | 4930438M06RIK, F-box and WD-40 domain protein 8, F-box and WD repeat domain containing 8, FBW6, FBW8, FBX29, FBXO29, FBXW6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXW8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- protein binding activity, bridging
- linker domain
- WD40
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- marginal zone cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- intrauterine growth retardation
role in cell
- proliferation
- degradation in
- expression in
- organization
- ubiquitination in
- K48 polyubiquitination in
- morphogenesis
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXW8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- cilium morphogenesis
- labyrinthine layer blood vessel development
- Golgi organization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of dendrite morphogenesis
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- centriole
- cilium basal body
- cytosol
- Golgi apparatus
- SCF ubiquitin ligase complex
- Cul7-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding