Dgkg Gene Summary [Mouse]
Enables ATP-dependent diacylglycerol kinase activity. Involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and negative regulation of phospholipase C/protein kinase C signal transduction. Predicted to be located in cytosol and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; integumental system; and sensory organ. Orthologous to human DGKG (diacylglycerol kinase gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgkg |
| Official Name | diacylglycerol kinase, gamma [Source:MGI Symbol;Acc:MGI:105060] |
| Ensembl ID | ENSMUSG00000022861 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase, gamma |
| Synonyms | 2900055E17Rik, DAGK3, DGK-GAMMA, DGK-III, DGK-γ, diacylglycerol kinase gamma, diacylglycerol kinase, gamma, diacylglycerol kinase γ, diacylglycerol kinase, γ, E430001K23Rik, mKIAA4131 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgkg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- diacylglycerol kinase
- EF-hand domain pair
- C1A domain
- EFh
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- Diacylglycerol kinase N-terminus
- lipid kinase, YegS/Rv2252/BmrU family
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- C1B domain
- Diacylglycerol kinase catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- obesity
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- major depression
- metabolic disorder
- spine abnormality
- survival
- acute myeloid leukemia
role in cell
- activation
- formation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- cell periphery
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgkg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendrite development
- negative regulation of protein kinase C signaling cascade
- glycerolipid metabolic process
- neuron development
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- lipid phosphorylation
- phosphatidic acid biosynthetic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium ion binding
- lipid binding
- diacylglycerol kinase activity