SFSWAP Gene Summary [Human]
This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
Details
| Type | Retained Intron |
| Official Symbol | SFSWAP |
| Official Name | splicing factor SWAP [Source:HGNC Symbol;Acc:HGNC:10790] |
| Ensembl ID | ENSG00000061936 |
| Bio databases IDs | |
| Aliases | splicing factor SWAP |
| Synonyms | 1190005N23RIK, 6330437E22RIK, AI197402, AW212079, SFRS8, splicing factor SWAP, Srsf8, SWAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SFSWAP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- Alternative splicing regulator
- Surp module
- protein binding
- Suppressor-of-White-APricot splicing regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SFSWAP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA 5'-splice site recognition
- negative regulation of nuclear mRNA splicing, via spliceosome
- alternative nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding