TPX2 Gene Summary [Human]
Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; mitotic spindle; and nucleoplasm. Colocalizes with spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TPX2 |
| Official Name | TPX2 microtubule nucleation factor [Source:HGNC Symbol;Acc:HGNC:1249] |
| Ensembl ID | ENSG00000088325 |
| Bio databases IDs | |
| Aliases | TPX2 microtubule nucleation factor, Targeting protein for Xklp2, differentially expressed in cancerous and noncancerous lung cells 2, hepatocellular carcinoma-associated antigen 519 |
| Synonyms | 2610005B21Rik, C20orf1, C20orf2, DIL-2, FLS353, GD:C20orf1, HCA519, HCTP4, p100, REPP86, RESTRICTED EXPRESSED PROLIFERATION ASSOCIATED protein 100, TPX2, microtubule-associated, TPX2 microtubule nucleation factor, TPX2, microtubule nucleation factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- destruction box
- protein kinase binding
- Targeting protein for Xklp2 (TPX2) domain
- coiled-coil domain
- Cell cycle regulated microtubule associated protein
- protein binding
- Aurora-A binding
- zDHHC ankyrin repeat binding domain
- KEN box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- hepatocellular carcinoma
- abdominal cancer
- epithelial cancer
- cancer
- epithelial neoplasia
- neoplasia
- liver cancer
- non-small cell lung cancer
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- expression in
- apoptosis
- function in
- proliferation
- accumulation in
- migration
- cell viability
- function
- quantity
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule aster fraction
- microtubule cytoskeleton
- spindle apparatus
- centrosome
- microtubules
- midbody
- cytoplasmic bridges
- asters
- cytosol
- nucleoplasm
- spindle pole
- spindle fibers
- axon hillock
- central spindle
- mitotic spindle
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- apoptotic process
- microtubule nucleation
- negative regulation of microtubule depolymerization
- activation of protein kinase activity
- regulation of mitotic spindle organization
- mitotic cell cycle
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- microtubule cytoskeleton
- mitotic spindle
- spindle pole
- spindle
- cytosol
- axon hillock
- nucleoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- binding, bridging