LIMCH1 Gene Summary [Human]
Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in stress fiber. Colocalizes with myosin II complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LIMCH1 |
| Official Name | LIM and calponin homology domains 1 [Source:HGNC Symbol;Acc:HGNC:29191] |
| Ensembl ID | ENSG00000064042 |
| Bio databases IDs | |
| Aliases | LIM and calponin homology domains 1 |
| Synonyms | 3732412D22Rik, KIAA1102, LIM and calponin homology domains 1, LIMC1, LIMCH1A, LMO7B, mKIAA1102, RGD1305269 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LIMCH1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- Neuroendocrine-specific golgi protein P55 (NESP55)
- Domain of unknown function (DUF4757)
- Calponin homology domain
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- calponin homology (CH) domain superfamily
- myosin II binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cleft lip
- COVID-19
- colorectal cancer
- soft tissue disorder
- vertigo
- osteoarthritis
- progression free survival
- migraine with aura
- overall survival
role in cell
- migration
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LIMCH1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of focal adhesion assembly
- positive regulation of stress fiber assembly
- actomyosin structure organization
- positive regulation of protein phosphorylation
- cytoplasmic actin-based contraction involved in cell motility
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- stress fiber
- myosin II complex
Molecular Function
What the gene product does at the molecular level
- actin binding
- metal ion binding
- myosin II head/neck binding