KLHL15 Gene Summary [Human]
This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. [provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | KLHL15 |
| Official Name | kelch like family member 15 [Source:HGNC Symbol;Acc:HGNC:29347] |
| Ensembl ID | ENSG00000174010 |
| Bio databases IDs | |
| Aliases | kelch like family member 15 |
| Synonyms | 6330500C13Rik, HEL-S-305, kelch-like 15, kelch-like family member 15, RGD1563101, XLID103 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHL15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding activity, bridging
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked mental retardation
- X-linked mental retardation type 103
role in cell
- damage in
- stabilization in
- turnover in
- ubiquitination in
- complexity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHL15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of double-strand break repair via homologous recombination
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding