YES1 Gene Summary [Human]
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | YES1 |
| Official Name | YES proto-oncogene 1, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12841] |
| Ensembl ID | ENSG00000176105 |
| Bio databases IDs | |
| Aliases | YES proto-oncogene 1, Src family tyrosine kinase |
| Synonyms | c-Yes, HsT441, p60c-yes, P61-YES, Yes, YES proto-oncogene 1, Src family tyrosine kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YES1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SH4 domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- epidermal growth factor receptor binding
- enzyme binding
- non-membrane spanning protein tyrosine kinase
- phosphotyrosine binding
- protein binding
- autophosphorylation site
- protein-tyrosine kinase
- Protein kinase domain
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- tyrosine kinase domain
- ion channel binding
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the YES1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Circadian Rhythm Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Ephrin A Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- HER-2 Signaling in Breast Cancer
- IL-15 Production
- Opioid Signaling Pathway
- Phagosome Formation
- Reelin Signaling in Neurons
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Sperm Motility
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- cardiovascular disorder
- acute lymphoblastic lymphoma
- precursor B-cell acute lymphoblastic leukemia
- obesity
- advanced phase chronic myeloid leukemia
- relapsed B cell acute lymphoblastic leukemia
- refractory chronic myeloid leukemia in accelerated phase
- Philadelphia-like B-cell acute lymphoblastic leukemia
role in cell
- phosphorylation in
- expression in
- activation in
- apoptosis
- assembly
- proliferation
- transformation
- cell viability
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- raft fractions
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell junction
- organelle
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- actin filaments
- cytosol
- apical cell surfaces
- caveolae
- acrosome
- synaptosomes
- zonula adherens
- lateral cell-cell contacts
- membrane rafts
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YES1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- T cell costimulation
- cellular response to platelet-derived growth factor stimulus
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of vascular permeability
- Fc-gamma receptor signaling pathway involved in phagocytosis
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- negative regulation of inflammatory response to antigenic stimulus
- regulation of glucose transport
- cellular response to transforming growth factor beta stimulus
- cellular response to retinoic acid
- innate immune response
- ephrin receptor signaling pathway
- cell differentiation
- leukocyte migration
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- focal adhesion
- cytosol
- Golgi apparatus
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- ion channel binding
- receptor binding
- enzyme binding