CHI3L2 Gene Summary [Human]
The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | CHI3L2 |
| Official Name | chitinase 3 like 2 [Source:HGNC Symbol;Acc:HGNC:1933] |
| Ensembl ID | ENSG00000064886 |
| Bio databases IDs | |
| Aliases | chitinase 3 like 2 |
| Synonyms | CHIL2, chitinase 3 like 2, CHONDROCYTE protein 39, HUMTCHIT, YKL-39 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHI3L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolases family 18
- GH18_chitinase-like
- enzyme
- chitin binding
- Glyco_18 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- latent tuberculosis
- cutaneous sarcoidosis
- breast cancer
- Alzheimer disease
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHI3L2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- chitin catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- chitinase activity
- chitin binding
- carbohydrate binding