CCNC Gene Summary [Human]

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
CCNC
Official Name
cyclin C [Source:HGNC Symbol;Acc:HGNC:1581]
Ensembl ID
ENSG00000112237
Bio databases IDs NCBI: 892 Ensembl: ENSG00000112237
Aliases cyclin C
Synonyms CG1C, CycC, cyclin C, hSRB11, SARCOLUMENIN, SRB11, SRCA
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCNC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cyclin box
  • Cyclin box fold superfamily
  • ubiquitin protein ligase activity
  • cyclin ccl1
  • Cyclin C-terminal domain
  • enzyme
  • domain present in cyclins, TFIIB and Retinoblastoma
  • protein binding
  • identical protein binding

Pathways

Biological processes and signaling networks where the CCNC gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • hereditary gingival fibromatosis
  • autosomal recessive polycystic kidney disease
  • hypoplasia
  • growth failure
regulated by
  • testosterone
  • insulin
  • TX-527
  • PTEN
  • carbon tetrachloride
  • ESR1
  • silibinin
  • 26S proteasome
  • sirolimus
  • sulforafan
regulates
role in cell
  • expression in
  • apoptosis
  • activation in
  • adhesion
  • accumulation in
  • survival
  • phagocytosis by
  • permeabilization
  • differentiation
  • autophagy in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • Cytoplasm
  • Mitochondria
  • cytoplasmic particles
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CCNC gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • G0 to G1 transition
  • negative regulation of Notch signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cyclin-dependent protein kinase holoenzyme complex
  • mediator complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • identical protein binding
  • cyclin-dependent protein kinase regulator activity
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.