ALKBH5 Gene Summary [Human]
Enables mRNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Located in Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ALKBH5 |
| Official Name | alkB homolog 5, RNA demethylase [Source:HGNC Symbol;Acc:HGNC:25996] |
| Ensembl ID | ENSG00000091542 |
| Bio databases IDs | |
| Aliases | alkB homolog 5, RNA demethylase |
| Synonyms | ABH5, alkB homolog 5, RNA demethylase, AW050020, AW215868, E130207K11, OFOXD, OFOXD1, RGD1309496 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALKBH5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-oxoglutarate:oxygen oxidoreductase
- protein binding activity, bridging
- demethylase activity
- enzyme
Pathways
Biological processes and signaling networks where the ALKBH5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- non-small cell lung cancer
- glioblastoma
- azoxymethane/dextran sodium sulfate induced colorectal cancer
- neoplasia
- liver cancer
- colorectal cancer
- oligozoospermia
- gastric cancer
- organismal death
role in cell
- proliferation
- expression in
- phosphorylation in
- glycolysis in
- growth
- degradation in
- apoptosis
- G1 phase
- quantity
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALKBH5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- mRNA export from nucleus
- mRNA destabilization
- regulation of mRNA processing
- response to hypoxia
- gamma-delta T cell proliferation
- spermatogenesis
- cell differentiation
- mRNA processing
- regulation of mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- paraspeckles
- nuclear speck
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- metal ion binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
- oxidative RNA demethylase activity