CRMP1 Gene Summary [Human]
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | CRMP1 |
| Official Name | collapsin response mediator protein 1 [Source:HGNC Symbol;Acc:HGNC:2365] |
| Ensembl ID | ENSG00000072832 |
| Bio databases IDs | |
| Aliases | collapsin response mediator protein 1 |
| Synonyms | collapsin response mediator protein 1, DPYSL1, DRP-1, Tuc-1a, ULIP-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRMP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- allantoinase
- cytoskeletal protein binding
- Amidohydrolase family
- phosphoprotein binding
- enzyme
- protein binding
- metallo-dependent_hydrolases
- identical protein binding
- D-hydantoinase
Pathways
Biological processes and signaling networks where the CRMP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- survival
- refractive error
- dysphagia
- cleft palate
- cleft lip
- infection by vesicular stomatitis virus
role in cell
- apoptosis
- activation in
- formation in
- migration
- invasion
- growth
- formation
- quantity
- invasiveness
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- presynaptic regions
- postsynaptic region
- actin cytoskeleton
- Nucleus
- centrosome
- midbody
- cytosol
- growth cone
- neuritic shafts
- cellular protrusions
- mitotic spindle
- perikaryon
- dendrites
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRMP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyrimidine base catabolic process
- negative regulation of neuron projection development
- nervous system development
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- growth cone
- centrosome
- spindle
- cytosol
- midbody
- perikaryon
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- identical protein binding
- protein binding
- dihydropyrimidinase activity
- filamin binding