ROCK2 Gene Summary [Human]
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ROCK2 |
| Official Name | Rho associated coiled-coil containing protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:10252] |
| Ensembl ID | ENSG00000134318 |
| Bio databases IDs | |
| Aliases | Rho associated coiled-coil containing protein kinase 2 |
| Synonyms | B230113H15RIK, KIAA0619, mKIAA0619, Rho-associated coiled-coil containing protein kinase 2, Rho-kinase, ROCK alpha, ROCK-II, ROCK α, ROK, ROKA, ROK alpha, ROK α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ROCK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p21 binding domain
- protein serine/threonine kinase
- protein kinase
- granzyme B cleavage site
- RhoA binding domain
- Synaptonemal complex protein 1 (SCP-1)
- Rho Binding
- helix-rich Mycoplasma protein
- Protein kinase domain
- protease activator
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- Tyrosine kinase, catalytic domain
- HOOK protein coiled-coil region
- HR1
- GTPase binding domain
- exonuclease SbcC
- Protein kinase (unclassified specificity)
- protease binding
- catalytic domain
- Hyaluronan mediated motility receptor N-terminal
- helical domain
- enzyme regulator activity
- protein binding
- Pleckstrin homology-like domain
- Calcium binding and coiled-coil domain (CALCOCO1) like
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Domain of unknown function (DUF4686)
- kinase domain
- Protein Kinases, catalytic domain
- cysteine-histidine rich domain
- Intermediate filament protein
- Rho-binding domain
- Septation ring formation regulator, EzrA
Pathways
Biological processes and signaling networks where the ROCK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- CCR3 Signaling in Eosinophils
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Ephrin A Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gα12/13 Signaling
- NGF Signaling
- PCP pathway
- PEDF Signaling
- RhoA Signaling
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Thrombin Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- squamous cell cancer
- Alzheimer disease
- endometriosis
- prostate cancer
- chronic graft-vs-host disease
- Huntington disease
- Fuchs endothelial dystrophy
- obesity
role in cell
- expression in
- replication in
- phosphorylation in
- quantity
- number
- growth
- apoptosis
- cell death
- cell cycle progression
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoplasmic ribonucleoprotein granule
- cell borders
- cell periphery
- perinuclear region
- cellular membrane
- centrosome
- Mitochondria
- cytosol
- neuromuscular junctions
- synapse
- early endosomes
- myosin filaments
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ROCK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- mRNA destabilization
- regulation of stress fiber assembly
- regulation of cellular response to hypoxia
- regulation of circadian rhythm
- protein phosphorylation
- positive regulation of fibroblast growth factor production
- cellular response to testosterone stimulus
- cortical actin cytoskeleton organization
- response to ischemia
- smooth muscle contraction
- cytokinesis after mitosis
- positive regulation of cardiac muscle hypertrophy
- negative regulation of biomineral tissue development
- positive regulation of endothelial cell migration
- positive regulation of connective tissue growth factor production
- response to transforming growth factor beta stimulus
- regulation of establishment of cell polarity
- regulation of keratinocyte differentiation
- aortic valve morphogenesis
- actomyosin structure organization
- positive regulation of MAPK cascade
- Rho protein signal transduction
- I-kappaB kinase/NF-kappaB cascade
- negative regulation of nitric oxide biosynthetic process
- negative regulation of gene expression
- regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- rhythmic process
- embryonic morphogenesis
- positive regulation of stress fiber assembly
- centrosome duplication
- negative regulation of myosin-light-chain-phosphatase activity
- positive regulation of gene expression
- positive regulation of centrosome duplication
- positive regulation of protein phosphorylation
- epithelial to mesenchymal transition
- regulation of cell motility
- regulation of cell adhesion
- regulation of neurological system process
- actin cytoskeleton organization
- peptidyl-threonine phosphorylation
- protein localization in plasma membrane
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoskeleton
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- structural molecule activity
- protease binding
- protein serine/threonine kinase activity
- tau-protein kinase activity
- ATP binding
- protein binding
- RNA binding
- metal ion binding
- tau protein binding
- small GTPase binding
- Rho-dependent protein serine/threonine kinase activity