SCARF1 Gene Summary [Human]
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Details
| Type | Protein Coding |
| Official Symbol | SCARF1 |
| Official Name | scavenger receptor class F member 1 [Source:HGNC Symbol;Acc:HGNC:16820] |
| Ensembl ID | ENSG00000074660 |
| Bio databases IDs | |
| Aliases | scavenger receptor class F member 1, scavenger receptor expressed by endothelial cells, acetyl LDL receptor |
| Synonyms | AA986099, mKIAA0149, scavenger receptor class F member 1, scavenger receptor class F, member 1, SREC, SREC1, SREC-I |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCARF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- scavenger receptor
- cytoplasmic domain
- protein binding
- low-density lipoprotein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glomerulonephritis
- systemic lupus erythematosus
- proteinuria
- androgenic alopecia
- cerebral aneurysm
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- alopecia
- hematuria
role in cell
- activation in
- formation
- aggregation
- outgrowth
- morphology
- number
- internalization by
- function
- regeneration
- shape change
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- cell surface
- cellular membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCARF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of axon regeneration
- cholesterol catabolic process
- heterophilic cell-cell adhesion
- positive regulation of neuron projection development
- neuron remodeling
- receptor-mediated endocytosis
- dendrite development
Cellular Component
Where in the cell the gene product is active
- membrane
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- scavenger receptor activity
- low-density lipoprotein particle binding