EIF3E Gene Summary [Human]
Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Located in cytosol and nucleus. Part of eukaryotic translation initiation factor 3 complex. Colocalizes with PML body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EIF3E |
| Official Name | eukaryotic translation initiation factor 3 subunit E [Source:HGNC Symbol;Acc:HGNC:3277] |
| Ensembl ID | ENSG00000104408 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3 subunit E |
| Synonyms | Eif3el1, eIF3-p46, EIF3-P48, EIF3S6, eukaryotic translation initiation factor 3 subunit E, eukaryotic translation initiation factor 3, subunit E, INT6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF3E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- nuclear export signal
- PCI domain
- nuclear localization sequence
- ion channel binding
- translation initiation factor
- eukaryotic translation initiation factor 3 subunit E
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the EIF3E gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- rheumatoid arthritis
- androgenic alopecia
- male pattern hair loss
- non-small cell lung cancer
- breast carcinoma
- lung carcinoma
- lung carcinoma process
- chronic obstructive pulmonary disease
- alopecia
role in cell
- phosphorylation in
- expression in
- binding in
- growth
- accumulation in
- proliferation
- migration
- invasiveness
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytoplasmic aggregates
- metaphase plate
- cytosol
- chromosome
- PML nuclear bodies
- central spindle
- mitotic spindle
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF3E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translational initiation
- positive regulation of translation
- formation of translation initiation complex
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- regulation of translational initiation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- PML body
- eukaryotic 48S preinitiation complex
- chromatin
- nucleoplasm
- eukaryotic translation initiation factor 3 complex
- nucleus
- extracellular vesicular exosome
- cytoplasm
- eukaryotic 43S preinitiation complex
- eukaryotic translation initiation factor 3 complex, eIF3e
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- RNA binding
- cadherin binding