FGF4 Gene Summary [Human]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FGF4 |
| Official Name | fibroblast growth factor 4 [Source:HGNC Symbol;Acc:HGNC:3682] |
| Ensembl ID | ENSG00000075388 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 4, human stomach cancer, transforming factor from FGF-related oncogene, kaposi sarcoma oncogene, transforming protein KS3 |
| Synonyms | Fgf7a, Fgfk, fibroblast growth factor 4, HBGF-4, HST, HST-1, HSTF-1, K-FGF, KS3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Translocation domain
- beta-trefoil_FGF
- cell penetrating signal sequence
- signal peptide
- signal sequence hydrophobic region
- protein binding
- growth factor
- hydrophobic domain
Pathways
Biological processes and signaling networks where the FGF4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- myelosuppression
- congenital malformation
- thrombocytopenia
- insulin resistance
- breast cancer metastatic to brain
- brain metastasis
- metastatic breast cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- differentiation
- apoptosis
- activation in
- degradation in
- expression in
- survival
- cell death
- proliferation
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cranial suture morphogenesis
- apoptotic process involved in morphogenesis
- positive regulation of cell proliferation
- fibroblast growth factor receptor signaling pathway
- odontogenesis of dentin-containing tooth
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cell division
- cartilage condensation
- stem cell proliferation
- somatic stem cell maintenance
- embryonic hindlimb morphogenesis
- chondroblast differentiation
- signal transduction
- cell-cell signaling
- positive regulation of MAPK cascade
- organ morphogenesis
- negative regulation of apoptotic process
- positive regulation of gene expression
- positive regulation of stem cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of endothelial cell chemotaxis to fibroblast growth factor
- regulation of cell migration
- mesenchymal cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- heparin binding
- fibroblast growth factor receptor binding