DUSP13 Gene Summary [Human]
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This gene encodes a dual specificity phosphatase that acts on both phosphotyrosine and phosphoserine/threonine residues. The encoded protein is expressed in testis. [provided by RefSeq, Mar 2023]
Details
| Type | Protein Coding |
| Official Symbol | DUSP13 |
| Official Name | dual specificity phosphatase 13 [Source:HGNC Symbol;Acc:HGNC:19681] |
| Ensembl ID | ENSG00000079393 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 13 |
| Synonyms | dual specificity phosphatase 13B, DUSP13, DUSP13A, Gm1203, LMW-DSP6, LOC108348179, MDSP, SKRP4, TMDP, TS-DSP6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DUSP13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- protein tyrosine/serine/threonine phosphatase
- phosphoprotein phosphatase
- phosphatase
- protein binding
- PTP_DSP_cys
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DUSP13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- negative regulation of MAPK cascade
- spermatogenesis
- protein dephosphorylation
- dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- MAP kinase phosphatase activity
- protein tyrosine phosphatase activity
- phosphatase activity
- myosin phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity