PROC Gene Summary [Human]
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Details
| Type | Retained Intron |
| Official Symbol | PROC |
| Official Name | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] |
| Ensembl ID | ENSG00000115718 |
| Bio databases IDs | |
| Aliases | protein C, inactivator of coagulation factors Va and VIIIa, prepro-protein C, coagulation factor XIV |
| Synonyms | PC, PROC1, Protein C, protein C, inactivator of coagulation factors Va and VIIIa, THPH3, THPH4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PROC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- Tryp_SPc
- peptidase
- Human growth factor-like EGF
- protein C (activated)
- protein binding
- identical protein binding
- EGF-like domain
- EGF_CA
- protease domain
- endopeptidase
- trypsin
- serine endopeptidase
- active site
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- Coagulation Factor Xa inhibitory site
Pathways
Biological processes and signaling networks where the PROC gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- thrombocytopenia
- COVID-19
- atherosclerosis
- stroke
- congenital protein C deficiency
- respiratory insufficiency
- autosomal dominant thrombophilia due to protein C deficiency
- Crohn disease
- autosomal recessive thrombophilia due to protein C deficiency
role in cell
- proliferation
- apoptosis
- activation in
- adhesion
- expression in
- activation
- migration
- generation in
- phosphorylation in
- necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cell surface
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- rough endoplasmatic reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PROC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of coagulation
- negative regulation of inflammatory response
- negative regulation of apoptotic process
- negative regulation of blood coagulation
- proteolysis
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- endoplasmic reticulum
- Golgi apparatus
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- serine-type endopeptidase activity