SDF4 Gene Summary [Human]
This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | SDF4 |
| Official Name | stromal cell derived factor 4 [Source:HGNC Symbol;Acc:HGNC:24188] |
| Ensembl ID | ENSG00000078808 |
| Bio databases IDs | |
| Aliases | stromal cell derived factor 4, calcium binding protein |
| Synonyms | CAB45, Stromal Cell-Derived Factor 4, Udp-gal beta-gal beta-1,3-galactosyltransferase, Udp-gal β-gal β-1,3-galactosyltransferase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SDF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- EF-hand domain pair
- calcium ion binding
- EFh
- EF-hand, calcium binding motif, found in CREC-EF hand family
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- infection by HIV-1
- infection by vesicular stomatitis virus
role in cell
- expression in
- apoptosis
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Golgi lumen
- perinuclear Golgi regions
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- endoplasmic reticulum lumen
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SDF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- cerebellum development
- UV protection
- calcium ion-dependent exocytosis
- fat cell differentiation
- zymogen granule exocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- late endosome
- bleb
- endoplasmic reticulum
- Golgi lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding