CDC37 Gene Summary [Human]
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC37 |
| Official Name | cell division cycle 37, HSP90 cochaperone [Source:HGNC Symbol;Acc:HGNC:1735] |
| Ensembl ID | ENSG00000105401 |
| Bio databases IDs | |
| Aliases | cell division cycle 37, HSP90 cochaperone, CDC37 cell division cycle 37 homolog, Hsp90 co-chaperone Cdc37, CDC37 (cell division cycle 37, S. cerevisiae, homolog) |
| Synonyms | cell division cycle 37, cell division cycle 37, HSP90 cochaperone, p50, P50CDC37 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cdc37 C terminal domain
- kinase binding
- protein kinase binding
- Cdc37 Hsp90 binding domain
- heat shock protein binding
- transcription factor binding
- protein kinase regulator
- protein binding
- chaperone binding
- Cdc37 N terminal kinase binding
Pathways
Biological processes and signaling networks where the CDC37 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- inflammatory bowel disease
- primary biliary cirrhosis
- COVID-19
- ankylosing spondylitis
- multiple sclerosis
- hyperplasia
- dysplasia
- tumorigenesis
- stromal fibrosis
role in cell
- expression in
- proliferation
- phosphorylation in
- activation in
- apoptosis
- growth
- degradation in
- endoplasmic reticulum stress response
- synthesis in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
- membrane ruffles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC37 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional regulation of gene expression
- protein targeting
- regulation of type I interferon-mediated signaling pathway
- protein folding
- regulation of interferon-gamma-mediated signaling pathway
- protein stabilization
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- heat shock protein binding
- scaffold protein binding
- protein binding
- chaperone binding
- Hsp90 protein binding
- unfolded protein binding
- protein kinase regulator activity
- kinase binding