HSPB11 Gene Summary [Human]
Predicted to enable metal ion binding activity. Predicted to be involved in kidney development and spermatogenesis. Predicted to act upstream of or within animal organ development; left/right axis specification; and skeletal system development. Predicted to be located in ciliary tip. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HSPB11 |
| Official Name | heat shock protein family B (small) member 11 [Source:HGNC Symbol;Acc:HGNC:25019] |
| Ensembl ID | ENSG00000081870 |
| Bio databases IDs | |
| Aliases | heat shock protein family B (small) member 11, intraflagellar transport 25 homolog (Chlamydomonas) |
| Synonyms | 2900042B11Rik, C1orf41, CFAP232, FAP232, HSP16.2, HSPB11, HSPCO34, intraflagellar transport 25, LOC683481, MGC897N, PP25 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSPB11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F5/8 type C domain
- protein binding
Pathways
Biological processes and signaling networks where the HSPB11 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ciliary tip
- cilia
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSPB11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- skeletal system development
- cilium morphogenesis
- kidney development
- spermatogenesis
- protein transport
- cell differentiation
- smoothened signaling pathway
- intraflagellar anterograde transport
- left/right axis specification
- lung development
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium
- intraflagellar transport particle B
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding