Hspb11 Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Involved in kidney development; smoothened signaling pathway; and spermatogenesis. Acts upstream of or within several processes, including left/right axis specification; lung development; and skeletal system development. Located in centrosome and cilium. Part of intraciliary transport particle B. Is expressed in embryo; germ cell of ovary; and secondary heart field. Orthologous to human IFT25 (intraflagellar transport 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspb11 |
| Official Name | heat shock protein family B (small), member 11 [Source:MGI Symbol;Acc:MGI:1920188] |
| Ensembl ID | ENSMUSG00000063172 |
| Bio databases IDs | |
| Aliases | heat shock protein family B (small), member 11 |
| Synonyms | 2900042B11Rik, C1orf41, CFAP232, FAP232, HSP16.2, HSPB11, HSPCO34, intraflagellar transport 25, LOC683481, MGC897N, PP25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspb11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F5/8 type C domain
- protein binding
Pathways
Biological processes and signaling networks where the Hspb11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- preweaning lethality complete penetrance
- abnormal atrioventricular cushion morphology
- abnormal behavior
- abnormal heart size
- abnormal neural tube morphology
- abnormal sternebra morphology
- atrioventricular septal defect
- cleft palate
- cyanosis
- decreased birth body size
- double outlet right ventricle
- fetal growth retardation
- increased circulating free fatty acid level
- increased circulating glycerol level
- left pulmonary isomerism
- micrognathia
- neonatal lethality complete penetrance
- omphalocele
- overriding aortic valve
- polydactyly
- preaxial polydactyly
- small thoracic cage
- unbalanced complete common atrioventricular canal
- ventricular septal defect
role in cell
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ciliary tip
- cilia
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hspb11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- skeletal system development
- cilium morphogenesis
- kidney development
- spermatogenesis
- protein transport
- cell differentiation
- smoothened signaling pathway
- intraflagellar anterograde transport
- left/right axis specification
- lung development
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium
- intraflagellar transport particle B
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding