TRAF3IP1 Gene Summary [Human]
The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | TRAF3IP1 |
| Official Name | TRAF3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:17861] |
| Ensembl ID | ENSG00000204104 |
| Bio databases IDs | |
| Aliases | TRAF3 interacting protein 1, microtubule interacting protein that associates with TRAF3 |
| Synonyms | 3930402D05Rik, CFAP116, FAP116, IFT54, MIP-T3, SLSN9, TRAF3 interacting protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAF3IP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Microtubule-binding protein MIP-T3 C-terminal region
- microtubule binding
- Microtubule-binding protein MIP-T3 CH-like domain
- tubulin binding
- coiled-coil domain
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Jeune syndrome
- Senior-Loken syndrome 9
- flu
- insomnia
- short-rib thoracic dysplasia type 6
- astigmatism
- psoriasis
role in cell
- binding
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ciliary transition zone
- fibrillar center
- ciliary tip
- cytoskeleton
- cilia
- basal bodies
- centrosome
- microtubules
- axonemes
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAF3IP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- regulation of microtubule cytoskeleton organization
- intraflagellar transport
- cilium morphogenesis
- kidney development
- negative regulation of protein phosphorylation
- negative regulation of protein complex assembly
- morphogenesis of a polarized epithelium
- intraflagellar anterograde transport
- negative regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium basal body
- cilium
- intraflagellar transport particle B
- ciliary transition zone
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding