BCORL1 Gene Summary [Human]
The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | BCORL1 |
| Official Name | BCL6 corepressor like 1 [Source:HGNC Symbol;Acc:HGNC:25657] |
| Ensembl ID | ENSG00000085185 |
| Bio databases IDs | |
| Aliases | BCL6 corepressor like 1 |
| Synonyms | 6720425J07RIK, B930011H20Rik, BCL6 co-repressor-like 1, CXorf10, RGD1566108, SHUVER |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCORL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- PCGF Ub-like fold discriminator and related domains
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- precursor B-cell acute lymphoblastic leukemia
- plasma cell myeloma
- acute lymphoblastic leukemia
- myelodysplastic syndrome
- acute myeloid leukemia
- T acute lymphoblastic leukemia
- Shukla-Vernon syndrome
- Wilms tumor
- Wilms tumorigenesis
regulated by
- sirolimus
- USP7
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BCORL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor activity