ASF1A Gene Summary [Human]
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ASF1A |
| Official Name | anti-silencing function 1A histone chaperone [Source:HGNC Symbol;Acc:HGNC:20995] |
| Ensembl ID | ENSG00000111875 |
| Bio databases IDs | |
| Aliases | anti-silencing function 1A histone chaperone |
| Synonyms | 2310079C17Rik, anti-silencing function 1A histone chaperone, CGI-98, CIA, HSPC146 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ASF1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- chromatin binding
- protein binding
- ASF1 like histone chaperone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung cancer
- systemic sclerosis
role in cell
- cell viability
- expression in
- binding in
- differentiation
- fusion
- olaparib resistance
- fitness
- acetylation in
- fusion in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ASF1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- muscle cell differentiation
- osteoblast differentiation
- replication fork processing
- nucleosome assembly
- DNA replication-dependent nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- chromatin binding