PCGF1 Gene Summary [Human]
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PCGF1 |
| Official Name | polycomb group ring finger 1 [Source:HGNC Symbol;Acc:HGNC:17615] |
| Ensembl ID | ENSG00000115289 |
| Bio databases IDs | |
| Aliases | polycomb group ring finger 1 |
| Synonyms | 2010002K04Rik, LOC103692167, NSPC1, polycomb group ring finger 1, RNF3A-2, RNF68 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCGF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- RAWUL domain RING finger- and WD40-associated ubiquitin-like
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PCGF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
- PcG protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding