SEH1L Gene Summary [Human]
The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SEH1L |
| Official Name | SEH1 like nucleoporin [Source:HGNC Symbol;Acc:HGNC:30379] |
| Ensembl ID | ENSG00000085415 |
| Bio databases IDs | |
| Aliases | SEH1 like nucleoporin, sec13 like protein, nucleoporin Seh1 |
| Synonyms | 2610007A16Rik, SEC13L, Seh1, SEH1A, SEH1B, SEH1-like, SEH1-like nucleoporin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEH1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the SEH1L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- metaphase plate
- cytosol
- lysosome membrane
- nuclear pores
- nuclear rim
- nuclear envelope
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEH1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- nucleocytoplasmic transport
- protein complex localization
- cellular response to nutrient levels
- nuclear pore organization
- cellular response to amino acid starvation
- protein transport
- mitotic metaphase plate congression
- mRNA transport
- defense response to Gram-positive bacterium
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- Nup107-160 complex
- Seh1-associated complex
- cytosol
- kinetochore
- lysosomal membrane
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity