BIRC2
BIRC2 Gene Summary
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Processed Transcript |
| Official Symbol | BIRC2 |
| Official Name | baculoviral IAP repeat containing 2 [Source:HGNC Symbol;Acc:HGNC:590] |
| Ensembl ID | ENSG00000110330 |
| Bio databases IDs | |
| Aliases | baculoviral IAP repeat containing 2, NFR2-TRAF signalling complex protein, apoptosis inhibitor 1 |
| Synonyms | API1,baculoviral IAP repeat-containing 2,C330006D17Rik,CIAP1,HIAP2,IAP-1,MIAP1,MIHB,rIAP1,RNF48 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- traf2 binding domain
- Bir domain
- transcription co-activator
- ubiquitin binding
- enzyme
- Ring finger domain
- protein binding
- cleavage site
- identical protein binding
- Caspase recruitment domain
- binding protein
- BIR
- transferase
- zinc ion binding
- spacer domain
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- chaperone binding
- Death Domain Superfamily of protein-protein interaction domains
- zinc-RING finger domain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the BIRC2 gene plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- Death Receptor Signaling
- Erythropoietin Signaling
- Induction of Apoptosis by HIV1
- Lymphotoxin β Receptor Signaling
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- Protein Ubiquitination Pathway
- RANK Signaling in Osteoclasts
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- APOE
- CD40
- EGFR
- PRKN
- MRE11
- IKBKG
- UBE2D2
- NTAQ1
- TRAF2
- UBA1
disease
- cancer
- neoplasia
- glioma formation
- epithelial cancer
- epithelial neoplasia
- liver neoplasia
- acute myeloid leukemia
- Huntington disease
- glioma
- liver cancer
regulated by
- 9,10-dimethyl-1,2-benzanthracene
- berberine
- tunicamycin
- reactive oxygen species
- TNF
- zerumbone
- MYC
- curcumin
- HTT
- doxorubicin
regulates
- paclitaxel
- CASP8
- CASP7
- CASP3
- CASP9
- XIAP
- IL6
- malondialdehyde
- IFNB1
- TNF
role in cell
- apoptosis
- cell death
- permeabilization
- molecular cleavage in
- activation in
- production in
- cell viability
- phosphorylation in
- expression in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- midbody
- cytosol
- cytoplasmic face of plasma membrane
- perinuclear space
- sex chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the BIRC2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to cAMP
- placenta development
- regulation of necroptosis
- negative regulation of necroptosis
- response to ethanol
- response to hypoxia
- regulation of cell differentiation
- positive regulation of transcription, DNA-dependent
- necroptosis
- apoptotic process
- regulation of reactive oxygen species metabolic process
- positive regulation of protein ubiquitination
- regulation of nucleotide-binding oligomerization domain containing signaling pathway
- regulation of cell cycle
- regulation of cysteine-type endopeptidase activity
- regulation of RIG-I signaling pathway
- regulation of toll-like receptor signaling pathway
- protein polyubiquitination
- NIK/NF-kappaB cascade
- regulation of apoptotic process
- cell surface receptor signaling pathway
- I-kappaB kinase/NF-kappaB cascade
- regulation of cell proliferation
- proteasomal ubiquitin-dependent protein catabolic process
- tumor necrosis factor-mediated signaling pathway
- negative regulation of apoptotic process
- regulation of innate immune response
- regulation of inflammatory response
CELLULAR COMPONENT
Where in the cell the gene product is active
- XY body
- nucleus
- cytoplasm
- cytosol
- CD40 receptor complex
- internal side of plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- identical protein binding
- protein binding
- ubiquitin binding
- transcription coactivator activity
- chaperone binding
- transferase activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process